Antibodies targeting talaromyces marneffei mp1p protein and methods of use thereof
OwnerKwok Yung Yuen, Jianpiao Cai +2inventors
InventorsKwok Yung Yuen, Jianpiao Cai, Fuk Woo Jasper Chan, Chiu Yat Patrick Woo
Life of this patent
Estimating the term…
Abstract
Provided are antibodies that specifically bind to a Talaromyces marneffei (T. marneffei) Mp1p protein. For example, such antibodies can be produced by a hybridoma cell line having the Patent Deposit Designation Number PTA-126527.
Claims24
An isolated antibody or antigen-binding portion thereof that specifically binds to a Talaromyces marneffei (T. marneffei) Mp1p protein and comprises:
- a heavy chain variable region comprising a heavy chain CDR1, a heavy chain CDR2, and a heavy chain CDR3 (heavy chain CDR1-3), and
- a light chain variable region comprising a light chain CDR1, a light chain CDR2, and a light chain CDR3 (light chain CDR1-3),
- wherein the heavy chain CDR1-3 and light chain CDR1-3 have the same sequences as the corresponding CDRs of the antibody produced by a hybridoma cell line having the Patent Deposit Designation Number PTA-126527.
A host cell that expresses an antibody that specifically binds to a Talaromyces marneffei (T. marneffei) Mp1p protein,
- wherein the antibody comprises:
- a heavy chain variable region comprising a heavy chain CDR1, a heavy chain CDR2, and a heavy chain CDR3 (heavy chain CDR1-3);
- and
- a light chain variable region comprising a light chain CDR1, a light chain CDR2, and a light chain CDR3 (light chain CDR1-3),
- wherein the heavy chain CDR1-3 and light chain CDR1-3 have the same sequences as the corresponding CDRs of the antibody produced by a hybridoma cell line having the Patent Deposit Designation Number PTA-126527,
- wherein the cell comprises a nucleic acid molecule or a vector encoding the antibody, and
- wherein the antibody is expressed from the nucleic acid molecule or vector in the host cell.
A hybridoma cell having the Patent Deposit Designation Number PTA-126527.
(canceled)
(canceled)
Dependencies are inferred from the claim text.