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US 2024/0199706 A1Published application
Immunomodulatory complex and uses thereof for therapy
AssigneeCommissariat A L'energie Atomique Et Aux Energies Alternatives
InventorsMichel LEONETTI, Alexandra SAVATIER, Celine COUSIN, Culina SLOBODAN
Life of this patent
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Abstract
The invention relates to a molecular complex consisting of at least one ligand of a sulphated sugar of the glycosaminoglycan family linked to at least one ligand of a surface molecule of antigen-presenting cells or NK or NKT cells, for use as an immunomodulatory drug, in particular in the immunotherapy of cancer and infectious diseases.
Claims21
1-16. (canceled)
An immunomodulatory composition, comprising at least one molecular complex,
- wherein said complex consists of at least one ligand of a sulfated sugar of the glycosaminoglycan family (first ligand) and at least one ligand of a surface molecule of antigen-presenting cells or of NK or NKT cells (second ligand), and
- wherein said ligands are bonded to one another and said complex is free of a specific antigen of the disease to be treated,
- and at least one pharmaceutically acceptable carrier, a carrier substance and/or an adjuvant.
Dependencies are inferred from the claim text.