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OwnerHo-Wook Jun, Brigitta Brott +4inventors
InventorsHO-WOOK JUN, BRIGITTA BROTT, XIXI ZHANG, JUN CHEN, JENNIFER SHERWOOD, PATRICK HWANG
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Disclosed are peptide amphiphiles comprising a hydrophilic peptide sequence and a hydrophobic tail, wherein the hydrophobic tail comprises a moiety having a substituted C5 alkyl chain, wherein the hydrophilic peptide sequence comprises a nitric oxide producing donor sequence. In some aspects, the hydrophilic peptide sequence comprises a degrading sequence (DS), wherein the degrading sequence (DS) comprises the amino acid sequence GTAGLIGQ (SEQ ID NO:1) wherein the DS comprises one or more amino acid substitutions. Also disclosed are compositions, liposomes, gels, and medical devices comprising the peptide amphiphiles and methods of use thereof.
A peptide amphiphile comprising a hydrophilic peptide sequence and a hydrophobic tail, wherein the hydrophobic tail comprises a moiety having a substituted C5 alkyl chain or a substituted C16 alkyl chain, wherein the hydrophilic peptide sequence comprises a nitric oxide producing donor sequence.
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A gel comprising a peptide amphiphile, wherein the peptide amphiphile a hydrophilic peptide sequence and a hydrophobic tail, wherein the hydrophobic tail comprises a moiety having an optionally substituted C16 alkyl chain, wherein the hydrophilic peptide sequence comprises a nitric oxide producing donor sequence comprising an amino acid sequence KKKKK (SEQ ID NO:3) and also comprises a degrading sequence (DS) comprising an amino acid sequence GTAGLIGQ (SEQ ID NO:1), wherein one or more of the Lys residues of the peptide amphiphile comprises a pendant amine group, wherein one or more molecules of nitric oxide is bound to at least one pendant amine group.
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A composition comprising a peptide amphiphile, wherein the peptide amphiphile comprises a hydrophilic peptide sequence and a hydrophobic tail, wherein the hydrophobic tail comprises a moiety having a substituted a substituted C16 alkyl chain, wherein the hydrophilic peptide sequence comprises a nitric oxide producing donor sequence wherein the nitric oxide producing donor sequence comprises the amino acid sequence Lys-Lys-Lys-Lys-Lys (KKKKK) (K5;
Dependencies are inferred from the claim text.