Heptapeptide amides for use in the treatment of hmgb1-dependent diseases

Abstract

The present invention relates to a compound of formula (I): where Z is (II) in which R1 and R2 are identical or different and are hydrogen or a lower alkyl chain having up to 4 carbon atoms or a pharmaceutically acceptable salt thereof. Further, the present invention relates to pharmaceutical compositions or dependent inflammatory or autoimmune disease selected from the group consisting of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, periodontitis, allergic rhinitis, chronic rhinosinusitis without nasal polyps, chronic rhinosinusitis with nasal polyps, pneumonia, chronic obstructive pulmonary disease, asthma, acute adult respiratory syndrome, diabetic macroangiopathy, diabetic coronary artery disease, peripheral arterial disease, diabetic cerebrovascular disease, diabetic microangiopathy, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, diabetic cardiomyopathy, diabetic foot ulceration, colitis, inflammatory bowel disease, and ocular disease. Preferably, the pharmaceutically acceptable salt is acetate.

Dependencies are inferred from the claim text.