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US 2024/0199656 A1Published application
Boron neutron capture therapy (bnct) probe
AssigneeThe University of Tokyo
InventorsYasuteru URANO, Mako KAMIYA, Junya TSUNETOMI
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Abstract
[Problem] To provide a novel compound promising as a probe for a boron neutron capture therapy (BNCT). [Solution] A compound represented by general formula (I) below or a salt thereof.
Claims22
A compound represented by the following General Formula (I) or a salt thereof.
- in the formula,
- X is selected from the group consisting of a fluorine atom, an ester group (—OC(═O)—R′), a carbonate group (—OCO2—R′), a carbamate group (—OCONH—R′), phosphoric acid and an ester group thereof (—OP(═O)(—OR′)(—OR″)), and sulfuric acid and an ester group thereof (—OSO2—OR′),
- where R′ and R″ are each independently selected from a substituted or unsubstituted alkyl group or a substituted or unsubstituted aryl group;
- Y is —NH—CO-L, —NH-L′, or —OL′,
- where L is a partial structure of an amino acid,
- L′is a saccharide or a partial structure of a saccharide, a saccharide having a self-cleaving linker, or an amino acid or a peptide having a self-cleaving linker;
- R1 and R2 are each independently selected from a hydrogen atom or a monovalent substituent;
- R3 is a hydrogen atom or one to three identical or different monovalent substituents present on a benzene ring;
- Z represents a single bond or a linking group;
- and
- B represents a group containing 10B.
8 more elements
Dependencies are inferred from the claim text.