Ctla-4 small molecule degradation agent and application thereof

A compound with the structure of formula I or a pharmaceutically acceptable salt, an ester, a deuterated product, an isomer, a solvate, a prodrug, or an isotopic label thereof:

• wherein,
• A, B, C, D, E, F, G, H, I, J, K, L, and M are independently selected from a direct bond, CR6, CR6R14, N, NR7, O, S and C═O;
• each of R1, R2, R3, R6, R7 and R14 is independently selected from hydrogen, deuterium, an unsubstituted or substituted alkyl group, an unsubstituted or substituted alkenyl group, an unsubstituted or substituted alkynyl group, an unsubstituted or substituted cycloalkyl group, an unsubstituted or substituted heterocycloalkyl group, halogen, —OH, an unsubstituted or substituted alkoxy group, an unsubstituted or substituted arylalkyl group, an unsubstituted or substituted heteroaryl alkyl group, an unsubstituted or substituted aryl ether group, an unsubstituted or substituted heteroaryl ether group, —CN, —N(R4R5), —NO2, —N3, a boronic acid group, an unsubstituted or substituted boronic ester group, a carboxyl group, an ester group, an unsubstituted or substituted carbamoyl group, an unsubstituted or substituted aryl group, an unsubstituted or substituted heteroaryl group, an unsubstituted or substituted thioether group, an unsubstituted or substituted sulfoxide group, an unsubstituted or substituted sulfone group, an unsubstituted or substituted sulfonamide group,
• an unsubstituted or substituted phosphate ester group, wherein R4, R5, R8, R9, R10 and R11 are independently selected from hydrogen, deuterium, a C1-6 alkyl group, a C3-7 cycloalkyl group, an unsubstituted or substituted aryl group, an unsubstituted or substituted heteroaryl group, R4 and R5, R8 and R9 can be connected with adjacent nitrogen atoms or carbon atoms to form a ring;
• or two adjacent R1 and/or two adjacent R3 can also be connected to form an unsubstituted or substituted cycloalkyl group, an unsubstituted or substituted heterocycloalkyl group, an unsubstituted or substituted aryl group or an unsubstituted or substituted heteroaryl group;
• m, n and o are independently selected from integers from 0 to 4;
• W is selected from the direct bond, an unsubstituted or substituted aryl group, an unsubstituted or substituted heteroaryl group, an unsubstituted or substituted cycloalkyl group, an unsubstituted or substituted heterocycloalkyl group, an unsubstituted or substituted bridged cycloalkyl group, an unsubstituted or substituted bridged heterocycloalkyl group, an unsubstituted or substituted spiro cycloalkyl group, an unsubstituted or substituted spiro heterocycloalkyl group, an unsubstituted or substituted alkyl group, an unsubstituted or substituted heteroalkyl group, an unsubstituted or substituted alkenyl group, an unsubstituted or substituted heteroalkenyl group, an unsubstituted or substituted alkynyl group, an unsubstituted or substituted heteroalkynyl group, an unsubstituted or substituted —N(R12R13), an unsubstituted or substituted aminoalkyl group, an unsubstituted or substituted aminoalkylamino group, an unsubstituted or substituted
• an unsubstituted or substituted
• wherein R12 and R13 are independently selected from hydrogen, deuterium, an unsubstituted or substituted C1-6 alkyl group, a C3-7 cycloalkyl group, an unsubstituted or substituted alkylamino group, an unsubstituted or substituted aryl group, an unsubstituted or substituted heteroaryl, or R12 and R13 can be connected to form a ring;
• Q is —H, —NH2, —OH, -alkyl-NHC(═O)H, a cycloalkyl group, an unsubstituted or substituted alkylacyl group, an unsubstituted or substituted alkylhydroxy group, an unsubstituted or substituted alkenylhydroxy group, an unsubstituted or substituted alkynylhydroxy group, an unsubstituted or substituted alkylamino group, an unsubstituted or substituted sulfonamide group, an unsubstituted or substituted alkylsulfonamide group, an amino acid residue,
• a sulfonamide group, a sulfonyl hydrazine group, an unsubstituted or substituted aryl group, an unsubstituted or substituted heteroaryl group, an unsubstituted or substituted
• an unsubstituted or substituted
• an unsubstituted or substituted —(CH2)n1-(M)n2-(CH2)n3-(M)n4-(CH2)n5-(M)n6, wherein each M is independently selected from O, OH, S, SO, SO2 and an unsubstituted or substituted amino group, each n1, n2, n3, n4, n5, and n6 are independently selected from integers from 0 to 6;
• or W and Q can be connected or fused to form a substituted or unsubstituted cycloalkyl group, a heterocycloalkyl group, an aryl group, or a heteroaryl group.