4-aminopyrrolo[2,1-f][1,2,4]triazines and preparation and uses thereof

A compound, or a pharmaceutically acceptable salt thereof, of Formula I:

• wherein:
• R1 is (9-10 membered heteroaryl) optionally substituted with 1-10 R4;
• R2 is selected from the group consisting of unsubstituted —(C1-9 alkyl), unsubstituted —(C2-9 alkenyl), unsubstituted —(C2-9 alkynyl), unsubstituted —(C1-9 haloalkyl), -heterocyclyl optionally substituted with 1-10 R5 and —(C1-5 alkylene)pcarbocyclyl optionally substituted with 1-12 R6, wherein the —(C1-5 alkylene) is optionally substituted with 1-5 halide and/or 1-3 unsubstituted —(C1-3 alkyl);
• R3 is selected from the group consisting of H, unsubstituted —(C1-6 alkyl), unsubstituted —(C2-6 alkenyl), unsubstituted —(C2-6 alkynyl), unsubstituted —(C1-6 haloalkyl), and -heterocyclyl optionally substituted with 1-10 R16;
• each R4 is independently selected from the group consisting of halide, unsubstituted —(C1-9 alkyl), unsubstituted —(C2-9 alkenyl), unsubstituted —(C2-9 alkynyl), unsubstituted —(C1-9 haloalkyl);
• each R5 is independently selected from the group consisting of halide, unsubstituted —(C1-9 alkyl), unsubstituted —(C2-9 alkenyl), unsubstituted —(C2-9 alkynyl), unsubstituted —(C1-9 haloalkyl), -heterocyclyl optionally substituted with 1-10 R7, -carbocyclyl optionally substituted with 1-12 R14, —(C1-5 alkylene)pOR8, and —C(═O)R9, wherein the —(C1-5 alkylene) is optionally substituted with 1-5 halide and/or 1-3 unsubstituted —(C1-3 alkyl);
• alternatively, two R5 attached to the same carbon atom are taken together to form a carbonyl group;
• each R6 is independently selected from the group consisting of halide, unsubstituted —(C1-9 alkyl), unsubstituted —(C2-9 alkenyl), unsubstituted —(C2-9 alkynyl), unsubstituted —(C1-9 haloalkyl), —CN, —(C1-5 alkylene)pOR10, —C(═O)R11, —NHC(═O)R12, and -carbocyclyl optionally substituted with 1-12 R14, wherein the —(C1-5 alkylene) is optionally substituted with 1-5 halide and/or 1-3 unsubstituted —(C1-3 alkyl);
• each R7 is independently selected from the group consisting of halide, unsubstituted —(C1-9 alkyl), unsubstituted —(C2-9 alkenyl), unsubstituted —(C2-9 alkynyl), unsubstituted —(C1-9 haloalkyl), —CN, and -carbocyclyl optionally substituted with 1-12 R4;
• each R8 is independently selected from the group consisting of H, unsubstituted —(C1-9 alkyl), unsubstituted —(C2-9 alkenyl), unsubstituted —(C2-9 alkynyl), and unsubstituted —(C1-9 haloalkyl);
• each R9 is independently selected from the group consisting of unsubstituted —(C1-9 alkyl), unsubstituted —(C2-9 alkenyl), unsubstituted —(C2-9 alkynyl), and unsubstituted —(C1-9 haloalkyl);
• each R10 is independently selected from the group consisting of H, unsubstituted —(C1-9 alkyl), unsubstituted —(C2-9 alkenyl), unsubstituted —(C2-9 alkynyl), unsubstituted —(C1-9 haloalkyl), and —(C1-5 alkylene)pOR8;
• each R11 is —N(R13)2;
• each R12 is independently selected from the group consisting of unsubstituted —(C1-9 alkyl), unsubstituted —(C2-9 alkenyl), unsubstituted —(C2-9 alkynyl), and unsubstituted —(C1-9 haloalkyl);
• each R13 is independently selected from the group consisting of H, unsubstituted —(C1-9 alkyl), unsubstituted —(C2-9 alkenyl), unsubstituted —(C2-9 alkynyl), and unsubstituted —(C1-9 haloalkyl);
• each R14 is independently selected from the group consisting of halide, unsubstituted —(C1-9 alkyl), unsubstituted —(C2-9 alkenyl), unsubstituted —(C2-9 alkynyl), and unsubstituted —(C1-9 haloalkyl);
• R15 is selected from the group consisting of H and halide;
• each R16 is independently selected from the group consisting of halide, unsubstituted —(C1-9 alkyl), unsubstituted —(C2-9 alkenyl), unsubstituted —(C2-9 alkynyl), and unsubstituted —(C1-9 haloalkyl);
• each p is independently 0 or 1;
• and
• wherein each H atom is optionally, independently replaced by 2H (D) (deuterium).