Map4k1 inhibitors

A compound of Formula I

• or a pharmaceutically acceptable salt thereof,
• wherein:
• T is selected from
• -L1-C(O)—NR11R12, -L1-O—C(O)—NR11R12 and -L2-NR13—C(O)—R14;
• Ring A is C4-6 cycloalkyl or 4-6 membered heterocycle containing nitrogen, wherein said cycloalkyl or heterocycle is optionally substituted with 1-2 R6;
• each R6 is independently selected from CH3, methoxy, CF3, CH2F, and CHF2;
• L1 and L2 are each independently selected from C1-C3 alkylene optionally substituted with 1-2 R15;
• each s is independently selected from 1, 2, and 3;
• B is O or NH;
• Q is N or CH;
• x is 0, 1, or 2;
• R1 and R2 are each independently selected from hydrogen, C1-6 alkyl, C3-6 cycloalkyl, and 4 to 6-membered heterocycle, wherein said alkyl is optionally substituted with 1-2 R3;
• each R3 is independently selected from halogen, hydroxyl and OR4;
• or
• each R4 is independently selected from C1-3 alkyl, CF3, CH2F, and CHF2;
• each R5 is independently selected from C1-2 alkyl, CF3, CH2F, and CHF2, or
• two R5 attached to the same carbon atom taken together with the carbon atom to which they attach form C3-5 cycloalkyl;
• or two R5 attached to two adjacent carbon atoms taken together with the two adjacent carbon atoms to which they attach form C4-6 cycloalkyl;
• n is 0, 1, 2, 3, or 4;
• R7 is selected from C1-3 alkyl, C3-6 cycloalkyl, OC1-4 alkyl, NR9R10, and 3-5 membered heterocycle containing nitrogen or oxygen, wherein said alkyl, cycloalkyl, or heterocycle is optionally substituted with 1-3 R8;
• each R8 is independently selected from halogen, C1-3 alkyl, CF3, CH2F, CHF2, hydroxyl, OC1-3 alkyl, OCF3, OCH2F, and OCHF2;
• R9 is selected from C1-2 alkyl;
• R10 is selected from C1-2 alkyl
• R11 is selected from C1-3alkyl;
• R12 is selected from C1-3 alkyl;
• or R11 and R12 taken together with the nitrogen atom to which they attach form 4 to 6-membered heterocycle containing nitrogen;
• R13 is H or C1-2alkyl;
• R14 is C1-3alkyl, or R13 and R14 taken together with the atoms to which attach form 4 to 6-membered heterocycle containing nitrogen;
• and
• each R15 is independently selected from halogen, methoxy, and C1-2alkyl, or two R15 taken together with the two adjacent carbon atoms to which they attach form cyclopropyl.