Anti-viral compounds

A compound of Formula (I), or a pharmaceutically acceptable salt thereof, having the structure:

• wherein:
• RN is hydrogen, deuterium or an unsubstituted or a substituted C1-6 alkyl;
• R1 is
• wherein Ring A1 is a 5-7 membered monocyclic heterocyclyl:
• i) includes NR5a in the ring;
• ii) is substituted with a first ═O on a carbon of the ring;
• iii) optionally includes 1-3 heteroatoms selected from the group consisting of O, S, S(═O)2, N and NR5b in the ring of Ring A1;
• iv) is optionally substituted with one or more moieties selected from the group consisting of a second ═O on a ring carbon, halogen, hydroxy, an unsubstituted C1-6 alkyl, an unsubstituted —O(C1-6 alkyl), an unsubstituted or a substituted phenoxy, an unsubstituted or a substituted C3-6 cycloalkyl, an unsubstituted or a substituted phenyl and an unsubstituted or a substituted benzyl;
• v) is optionally fused to an unsubstituted or a substituted phenyl, an unsubstituted or a substituted monocyclic heteroaryl, an unsubstituted or a substituted monocyclic heterocyclyl, an unsubstituted or a substituted bicyclic heteroaryl, an unsubstituted or a substituted bicyclic heterocyclyl, an unsubstituted or a substituted monocyclic cycloalkenyl or an unsubstituted or a substituted bicyclic cycloalkenyl;
• and
• vi) provided that when R1 is
• then Ring A2 can be an unsubstituted or a substituted monocyclic heterocyclyl, an unsubstituted or a substituted monocyclic cycloalkenyl or an unsubstituted or a substituted bicyclic cycloalkenyl;
• R2 is hydrogen, an unsubstituted or a substituted C1-8 alkyl, an unsubstituted or a substituted C2-8 alkenyl, an unsubstituted or a substituted C2-8 alkynyl, an unsubstituted or a substituted C3-10 cycloalkyl, an unsubstituted or a substituted C3-10 cycloalkenyl, an unsubstituted or a substituted aryl, an unsubstituted or a substituted aryl(alkyl), an unsubstituted or a substituted heteroaryl, an unsubstituted or a substituted heteroaryl(alkyl), an unsubstituted or a substituted heterocyclyl or an unsubstituted or a substituted heterocyclyl(alkyl);
• R3 is
• Z1 is —C(═O)— or —S(═O)2—;
• R4 is selected from the group consisting of cyano, an unsubstituted or a substituted C2-5 alkynyl, an unsubstituted or a substituted acyl, an unsubstituted or a substituted ketoamide, —C(═O)NH2, —CH(OH)—(S(═O)2—OH), —CH(OH)—(S(═O)2—O—), —CH(OH)((P═O)(OR6)2) and —C(═O)CH2—O—((P═O)(OR7)2);
• R5a is selected from the group consisting of hydrogen, an unsubstituted or a substituted C1-4 alkyl, an unsubstituted or a substituted C2-4 alkenyl and an unsubstituted or a substituted C3-6 cycloalkyl;
• R5b is selected from the group consisting of hydrogen, an unsubstituted or a substituted C1-4 alkyl, an unsubstituted or a substituted C2-4 alkenyl and an unsubstituted or a substituted C3-6 cycloalkyl;
• each R6 and each R7 are independently hydrogen, an unsubstituted C1-6 alkyl, an unsubstituted C2-6 alkenyl, an unsubstituted C1-6 haloalkyl, an unsubstituted or a substituted aryl or an unsubstituted or a substituted aryl(C1-4 alkyl);
• R8 and R10 are independently selected from the group consisting of an unsubstituted or a substituted C1-6 alkyl, an unsubstituted or a substituted C2-6 alkenyl, an unsubstituted or a substituted C2-6 alkynyl, an unsubstituted or a substituted monocyclic C3-6 cycloalkyl, an unsubstituted or a substituted bicyclic C5-8 cycloalkyl and an unsubstituted or a substituted monocyclic 4- to 6-membered heterocyclyl,
• wherein when the C1-6 alkyl is substituted, the C1-6 alkyl is substituted 1, 2, 3 or 4 times with a substituent independently selected from the group consisting of halogen, cyano, —NH2, an unsubstituted or a substituted monocyclic C3-6 cycloalkyl, an unsubstituted or a substituted bicyclic C5-6 cycloalkyl, an unsubstituted or a substituted phenyl, an unsubstituted or a substituted monocyclic 5- or 6-membered heteroaryl, an unsubstituted or a substituted monocyclic 4-6 membered heterocyclyl, an unsubstituted C1-4 alkoxy, an unsubstituted or a substituted phenoxy, an unsubstituted or a substituted —O—(CH2)-phenyl and an unsubstituted C1-4 haloalkoxy, or the C1-6 alkyl is substituted 1 to 13 times with deuterium;
• wherein when the C2-6 alkenyl, the C2-6 alkynyl, the monocyclic C3-6 cycloalkyl, the bicyclic C5-8 cycloalkyl and the monocyclic 4- to 6-membered heterocyclyl are substituted, the C2-6 alkenyl, the C2-6 alkynyl, the monocyclic C3-6 cycloalkyl, the bicyclic C5-8 cycloalkyl and the monocyclic 4- to 6-membered heterocyclyl are substituted 1, 2, 3 or 4 times with a substituent independently selected from the group consisting of halogen, an unsubstituted C1-4 alkyl, an unsubstituted C2-4 alkenyl, an unsubstituted C2-4 alkynyl, an unsubstituted C1-4 haloalkyl, an unsubstituted or a substituted monocyclic C3-6 cycloalkyl and an unsubstituted C1-4 alkoxy;
• and
• R8a is hydrogen or an unsubstituted C1-4 alkyl;
• or
• R8 and R8a are taken together to form an unsubstituted monocyclic C3-6 cycloalkyl or a halogen-substituted monocyclic C3-6 cycloalkyl;
• R9 is selected from the group consisting of an unsubstituted or a substituted C1-6 alkyl, an unsubstituted or a substituted C1-6 haloalkyl, an unsubstituted or a substituted monocyclic C3-6 cycloalkyl, an unsubstituted or a substituted bicyclic C5-6 cycloalkyl, an unsubstituted or a substituted phenyl, an unsubstituted or a substituted monocyclic heteroaryl, an unsubstituted or a substituted monocyclic heterocyclyl, an unsubstituted or a substituted alkoxy and —NR17R18, wherein the substituted C1-6 alkyl is substituted 1 or 2 times with a substituent selected from hydroxy and an unsubstituted C1-4 alkoxy, wherein the substituted monocyclic C3-6 cycloalkyl is substituted 1, 2, 3 or 4 times with a substituent independently selected from the group consisting of halogen, an unsubstituted C1-4 alkyl, an unsubstituted C1-4 alkoxy, an unsubstituted C1-4 haloalkyl and an unsubstituted monocyclic C3-6 cycloalkyl, and wherein the substituted C1-6 haloalkyl is substituted 1 or 2 times with an unsubstituted C1-4 alkoxy;
• R11 is an unsubstituted or a substituted monocyclic 4- to 6-membered heterocyclyl, —(NH)m-(an unsubstituted or a substituted 5- to 10-membered heteroaryl), —O-(an unsubstituted or a substituted C1-6 alkyl), —O-(an unsubstituted or a substituted C3-8 cycloalkyl) or —O—(C1-4 alkyl)−(an unsubstituted or a substituted C3-8 cycloalkyl), wherein m is 1;
• R12 is an unsubstituted or a substituted C1-8 alkyl, an unsubstituted or a substituted C2-8 alkenyl, an unsubstituted or a substituted C2-8 alkynyl, an unsubstituted or a substituted monocyclic C3-8 cycloalkyl, an unsubstituted or a substituted aryl, an unsubstituted or a substituted heteroaryl, an unsubstituted or a substituted 3- to 12-membered monocyclic heterocyclyl, an unsubstituted or a substituted 5- to 12-membered bicyclic heterocyclyl, an unsubstituted or a substituted aryl(alkyl), an unsubstituted or a substituted heteroaryl(alkyl), an unsubstituted or a substituted heterocyclyl(alkyl), an unsubstituted or a substituted C-carboxy, —OR13—NR14R15 or —C(═O)—NR16AR16B;
• R13 is an unsubstituted or a substituted C1-8 alkyl, an unsubstituted or a substituted C2-8 alkenyl, an unsubstituted or a substituted C2-8 alkynyl, an unsubstituted or a substituted monocyclic C3-8 cycloalkyl, an unsubstituted or a substituted aryl, an unsubstituted or a substituted heteroaryl, an unsubstituted or a substituted 3- to 8-membered monocyclic heterocyclyl, an unsubstituted or a substituted aryl(alkyl) or an unsubstituted or a substituted heteroaryl(alkyl);
• R14 are R15 are independently selected from the group consisting of hydrogen, an unsubstituted or a substituted C1-8 alkyl, an unsubstituted or a substituted C2-8 alkenyl, an unsubstituted or a substituted C2-8 alkynyl, an unsubstituted or a substituted monocyclic C3-8 cycloalkyl, an unsubstituted or a substituted aryl, an unsubstituted or a substituted heteroaryl, an unsubstituted or a substituted 3- to 8-membered monocyclic heterocyclyl, an unsubstituted or a substituted aryl(alkyl) or an unsubstituted or a substituted heteroaryl(alkyl);
• R16A is hydrogen or an unsubstituted C1-3 alkyl;
• R16B is an unsubstituted or a substituted aryl, an unsubstituted or a substituted heteroaryl or an unsubstituted or a substituted 3- to 8-membered monocyclic heterocyclyl;
• and
• R17 and R18 are independently selected from the group consisting of hydrogen, an unsubstituted or a substituted C1-8 alkyl, an unsubstituted or a substituted C2-8 alkenyl, an unsubstituted or a substituted C2-8 alkynyl, an unsubstituted or a substituted C3-8 cycloalkyl, an unsubstituted or a substituted 3-8 membered heterocyclyl, an unsubstituted or a substituted aryl, an unsubstituted or a substituted heteroaryl, an unsubstituted or a substituted aryl(alkyl) and an unsubstituted or a substituted heteroaryl(alkyl);
• or
• R17 and R18 are taken together along with the nitrogen to which they are connected to form an unsubstituted or a substituted 3-8 membered heterocyclyl.