Imidazo[1,2-b]pyridazine based tricyclic compounds as inhibitors of haspin and therapeutic uses thereof

A compound of formula (I):

• wherein:
• R1 is selected from the following groups:
• H, halo, CF3,
• R2a and R2b are independently selected from the following groups:
• H
• alkyl C1-C6 substituted by OH or by heterocycle, said heterocycle being optionally substituted by halo;
• cycloalkyl C3-C6 substituted by OH or by alkyl C1-C4;
• or R2a and R2b are linked and form a cycle together with the N atom to which they are attached, and R2a and R2b are the same or different alkylene C1-C3 optionally substituted by an alkyl C1-C4, said alkyl being optionally substituted by OH or by NH2;
• X and Y are independently selected from O, CH2, N(alkyl C1-C4) and R3 is an alkylene C1-C2 optionally substituted by alkyl C1-C4, with the proviso that one of X and Y must be O and that the cycle formed by X, Y and R3 is not aromatic;
• or a pharmaceutically acceptable ester, amide, solvate or salt thereof.