Heterocyclic compounds

A compound of formula (I)

• or a pharmaceutically acceptable salt thereof, wherein:
• X is CR8 or N;
• A is selected from
• B is a heteroaryl selected from B-1 to B-10:
• wherein the wavy line indicates the point of attachment to the remainder of formula (I);
• C is selected from C6-C14-aryl, C3-C10-cycloalkyl, 5- to 6-membered heteroaryl, and 3- to 14-membered heterocyclyl;
• D is selected from C3-C10-cycloalkyl, 3- to 14-membered heterocyclyl, C6-C14-aryl, and 5- to 14-membered heteroaryl;
• E is selected from C3-C10-cycloalkyl, and 3- to 14-membered heterocyclyl;
• L1 is selected from a covalent bond, —CR12R13—, —CH2O—, —OCH2—, —CH2NH—, —NHCH2—, —CH2OCH2—, —O—, —NH—, —CH2CH2—, —CH═CH—, —SO2NH—, —NHSO2—, —SO2NHCH2—, —CH2NHSO2—, —SO2—, —CH2SO2—, —SO2CH2—, —(CH2)2SO2—, —SO2(CH2)2—, carbonyl, —NHC(O)— and —C(O)NH—;
• L2 is selected from a covalent bond, —CH2—, —CH2NH—, —NHCH2—, —NH—, —N(C1-C6-alkyl)- and —SO2—;
• L3 is selected from a covalent bond and —CH2—;
• R1 is selected from hydrogen, halogen, a group L, C1-C6-alkyl, halo-C1-C6-alkyl, C1-C6-alkoxy, halo-C1-C6-alkoxy, C1-C6-alkyl-SO2NH—, C3-C10-cycloalkyl-C1-C6-alkyl-S(O)2—, C1—C-alkyl-SO2—, halo-C1-C6-alkyl-S(O)2—, (C1-C6-alkyl)2N—SO2—, and halo-C1-C6-alkyl-C(O)—;
• R2, R3, and R4 are each independently selected from hydrogen, halogen, C1-C6-alkyl, halo-C1-C6-alkyl, and 3- to 14-membered heterocyclyl;
• R5 and R6 are each independently selected from hydrogen, halogen, cyano, hydroxy, amino, C1-C6-alkyl, C1-C6-alkoxy, halo-C1-C6-alkyl, halo-C1-C6-alkoxy, C3-C10-cycloalkyl, and 3- to 14-membered heterocyclyl;
• wherein said C3-C10-cycloalkyl and 3- to 14-membered heterocyclyl are optionally substituted with 1, 2 or 3 substituents selected from C1-C6-alkyl, halo-C1-C6-alkyl, C1-C6-alkoxy, halo-C1-C6-alkoxy, halogen, cyano, amino, and hydroxy;
• R7 is absent or is selected from hydrogen, halogen, cyano, hydroxy, amino, C1-C6-alkyl, C1-C6-alkoxy, halo-C1-C6-alkyl, and halo-C1-C6-alkoxy;
• R8 is selected from hydrogen, halogen, cyano, C1-C6-alkyl, C1-C6-alkoxy, and hydroxy;
• R9 is selected from hydrogen, C1-C6-alkyl, C1-C6-alkoxy, halo-C1-C6-alkyl, halo-C1-C6-alkoxy, halogen, cyano, SF5, C1—C-alkyl-SO2—, halo-C1-C6-alkyl-SO2—, (C1-C6-alkyl)2-PO—, amino, carboxy, carboxy-C1-C6-alkyl, C1-C6-alkoxycarbonyl, C1-C6-alkoxycarbonyl-C1-C6-alkyl-, NH2SO2—, carbamoyl, C1-C6-alkyl-C(O)NH—, halo-C1-C6-alkyl-NHC(O)—, oxo, a group
• a group
• and a group
• R10 and R11 are each independently selected from hydrogen, halogen, cyano, C1-C6-alkyl, C1-C6-alkoxy, halo-C1-C6-alkyl, and oxo;
• R12 is selected from hydrogen, carbamoyl, C1-C6-alkyl-NHC(O)—, and halo-C6-C14-aryl and R13 is hydrogen;
• or
• R12 and R13, taken together with the carbon atom to which they are attached, form a C3-C10-cycloalkyl;
• R14 is selected from hydrogen, C1-C6-alkyl, halo-C1-C6-alkyl, C1-C6-alkoxy, halo-C1-C6-alkoxy, halogen, cyano, amino, carbamoyl, hydroxy, oxo, C1—C-alkyl-SO2—, and a group
• R15 is selected from hydrogen, halogen, hydroxy, oxo, and C1-C6-alkyl;
• R16 is selected from hydrogen and halogen;
• and
• R17 is selected from hydrogen, C1-C6-alkyl, and halo-C1-C6-alkyl.