Urea derivatives for treating uveal melanoma

A method of treating uveal melanoma comprising administering a compound of formula (I), a pharmaceutically acceptable salt thereof, a tautomer thereof, or a composition comprising said compound, pharmaceutically acceptable salt, or tautomer to a subject having uveal melanoma:

• in which:
• Y is 13 NH—, —S—, or —O—;
• R1 is a radical selected from the group consisting of:
• a hydrogen atom,
• a (C1-C6)alkyloxy group,
• a (C1-C6)alkyl group,
• a nitro group,
• a —NR3R4 group with R3 and R4 are independently a radical selected from the group consisting of:
• a hydrogen atom,
• a —COR5 with R5 is a (C1-C6)alkyl group, and
• a —SO2R6 with R6 is a (C1-C6)alkyl group,
• a halogen atom, and
• a 3-14 membered ring selected from the group consisting of an aryl, a heteroaryl, a cycloalkyl, and a heterocycloalkyl, said 3-14 membered ring is optionally substituted by a radical selected from the group consisting of a (C1-C6)alkyl group, a (C1-C6)alkyloxy group, a halogen atom, a nitro group, and a carboxyl group;
• R2 is a radical selected from the group consisting of:
• a hydrogen atom,
• a halogen atom,
• a (C1-C6)alkyloxy group, and
• a (C1-C6)alkyl group;
• n is an integer number from 0 to 5.

A compound, a pharmaceutically acceptable salt or a tautomer thereof, of formula (I):

• in which:
• Y is —S—, or —O—;
• R1 is a radical selected from the group consisting of:
• a nitro group, a —NR3R4 group with one of R3 or R4 is H and the other is a —SO2R6 with R6 is a (C1-C6)alkyl group, and
• a 3-14 membered ring selected from the group consisting of a thiophenyl, a furanyl, and a naphthalenyl, said 3-14 membered ring is optionally substituted by a radical selected from the group consisting of a (C1-C6)alkyl group, a (C1-C6)alkyloxy group, a halogen atom, a nitro group, and a carboxyl group;
• with the proviso that when R1 is a nitro group, then Y is —O—;
• R2 is a radical selected from the group consisting of:
• a hydrogen atom,
• a halogen atom,
• a (C1-C6)alkyloxy group, and
• a (C1-C6)alkyl group;
• and
• n is an integer number from 0 to 5.

A compound selected from the group consisting of:

• N-(2-(3-(3-chlorophenyl)ureido)benzo[d]thiazol-6-yl)acetamide (MCK149);
• N-(2-(3-(3-chlorophenyl)ureido)benzo[d]thiazol-6-yl)methanesulfonamide (MCK150);
• 1-(5-nitrobenzo[d]oxazol-2-yl)-3-phenylurea (MCK154);
• 1-(6-nitro-1H-benzo[d]imidazol-2-yl)-3-phenylurea (MCK157);
• 1-(3-chlorophenyl)-3-(5-nitrobenzo[d]oxazol-2-yl)urea (MCK158);
• 1-(3-chlorophenyl)-3-(6-nitrobenzo[d]oxazol-2-yl)urea (MCK160);
• 1-(3-chlorophenyl)-3-(6-(thiophen-2-yl)benzo[d]thiazol-2-yl)urea (MCK161);
• 1-(3-chlorophenyl)-3-(6-(furan-2-yl)benzo[d]thiazol-2-yl)urea (MCK162);
• 1-(3-chlorophenyl)-3-(6-(thiophen-3-yl)benzo[d]thiazol-2-yl)urea (MCK163);
• 1-(3-chlorophenyl)-3-(6-(naphthalen-1-yl)benzo[d]thiazol-2-yl)urea (MCK164);
• 1-(3,5-dichlorophenyl)-3-(6-ethoxybenzo[d]thiazol-2-yl)urea (MCK167);
• and
• 1-(3-chlorophenyl)-3-(6-(pyridin-2-yl)benzo[d]thiazol-2-yl)urea (MCK172).