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US 2024/0199556 A1Published application
Synthesis of 1,4-Diazaspiro[5.5]Undecan-3-One
AssigneeG1 Therapeutics, Inc.
InventorsStephen E. Schneider, Hannah White, Thomas Fessard, Sagar Beldar
Life of this patent
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Abstract
This invention provides a process for preparing 1,4-diazaspiro[5.5]undecan-3-one and analogues thereof that are useful in the preparation of pharmaceutical compound, including for the treatment of disorders involving abnormal cellular proliferation. Chemical intermediates in the process are also provided.
Claims20
1-10. (canceled)
A process to prepare a spirocyclic compound comprising:
- a. reducing a compound of Formula III with a reducing agent;
- b. cyclizing the compound of step (a);
- wherein Formula III is:
- wherein the spirocyclic compound is of Formula:
- wherein
- y is 0;
- n is 0 or 1;
- R1 is hydrogen;
- R2 is hydrogen, substituted heteroaryl, or
- R3 is hydrogen;
- R4 is NR8R9 or OR10;
- R5 and R6 are independently selected from the group consisting of hydrogen, alkyl, aryl, -alkyl-aryl, and —C(O)R11;
- R7 is alkyl, aryl, or -alkyl-aryl;
- R8 and R9 are independently selected from the group consisting of hydrogen, alkyl, aryl, and -alkyl-aryl;
- R10 is alkyl, aryl, or -alkyl-aryl;
- R11 is alkyl or aryl;
- R12 is alkyl, aryl, or -alkyl-aryl;
- and
- R13 is —S-alkyl or Cl.
16 more elements
27-72. (canceled)
Dependencies are inferred from the claim text.