Novel compounds useful as sting agonists and uses thereof

A compound, or a pharmaceutically acceptable salt, wherein the compound is of general formula I:

• or the compound is of general formula II,
• or the compound is of general formula III,
• each W is independently selected from CR1 or N;
• each R1 is independently selected from H, deuterium, halogen, OR6, N(R6)2, COOR6, or C(O)N(R6)2, CN or C1-C6 alkyl;
• wherein the C1-C6 alkyl is optionally substituted with one or more deuterium, halogen, OR6, N(R6)2, COOR6, or C(O)N(R6)2;
• R2 and R3 are independently selected from the group consisting of O—(C0-C4 alkylene or haloalkylene), C1-C5 alkylene or haloalkylene, N(R6)—(C1-C4 alkylene or haloalkylene), -Ta-C1-C6 alkyl-Tb-, -Ta-N(Rs)-Tb, -Ta-O-Tb, -Ta-PEGn-O-Tb, -Ta-S—S-Tb, -Ta-S—S—S-Tb, -Ta-N(R)—N(Rs)-Tb-, -Ta-C2-C6 alkenyl-Tb-, -Ta-C2-C6 alkynyl-Tb-, -Ta-C(═O)-Tb—, -Ta-C(═CH2)-Tb—, -Ta-C(═O)—C(═O)-Tb-, -Ta—C(═O)—(C1-C6 alkyl)-C(═O)-Tb—, -Ta-C(═O)—(C3-C12 cycloalkyl)-C(═O)-Tb—, -Ta-C(═O)—(C1-C6 alkyl)-(C3-C12 cycloalkyl)-(C1-C6 alkyl)-C(═O)-Tb—, -Ta-C(═O)-(3- to 12-membered heterocycloalkyl)-C(═O)-Tb—, -Ta-C(═O)—(C1-C6 alkyl)-(3- to 12-membered heterocycloalkyl)-(C1-C6 alkyl)-C(═O)-Tb—, -Ta-C(═S)-Tb—, -Ta-S(═O)2-Tb—, -Ta-S(═O)-Tb—, -Ta-P(═O)(—ORs)-Tb-, -Ta-(C3-C12 cycloalkyl)-Tb-, -Ta-(C6-C12 aryl)-Tb-, -Ta-(3- to 12-membered heterocycloalkyl)-Tb-, or -Ta-(5- to 12-membered heteroaryl)-Tb-, wherein the C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C12 cycloalkyl, C6-C12 aryl, 3- to 12-membered heterocycloalkyl, or 5- to 12-membered heteroaryl is optionally substituted with one or more deuterium, halo, —ORs, —N(Rs)2, or —C(═O)ORs;
• PEGn is (—OCH2CH2—)n, n=1-8;
• Ta and Tb each independently are absent, —N(Rs)—, —O—, C1-C6 alkyl, —N(Rs)—(C1-C6 alkyl)-, —(C1-C6 alkyl)-N(Rs)—, —N(Rs)—(C1-C6 alkyl)-N(Rs)—, —O—(C1-C6 alkyl)-, —(C1-C6 alkyl)-O—, or —O— (C1-C6 alkyl)-O—;
• wherein the C1-C6 alkyl is optionally substituted with one or more halogen;
• and
• each Rs independently is H, deuterium or C, —C6 alkyl optionally substituted with one or more halogen;
• each R4 is independently selected from the group consisting of H, deuterium, halogen, CN, OR6, N(R6)2, COOR6, C(O)N(R6)2, SO2R6, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkyl substituted by OR6, C2-C6 alkenyl, C2-C6 haloalkenyl, C2-C6 alkenyl substituted by OR6, C2-C6 alkynyl, C2-C6 haloalkynyl, C2-C6 alkynyl substituted by OR6, C3-C6 cycloalkyl, and a 3- to 6-membered heterocyclic ring including 1 to 2 ring members selected from the group consisting of O, S, and N(R6);
• each R6 is independently selected from the group consisting of —H, deuterium, halogen, —NH2, —CN, —OH, —N3, —NO2, carboxyl, C1-6 alkyl, C1-6 alkoxy, C2-6 alkenyl, C2-6 alkynyl, —C6-10 aryl, —C5-10 heteroaryl, C3-10 heterocyclic ring or C3-10 carbocyclic ring, and each of which is independently optionally substituted with deuterium, halogen, —NH2, —CN, —OH, —NO2, carbonyl, ═O, oxo, carboxyl, C1-6 alkoxy, or C1-6 alkyl;
• and each of the heteroaryl and heterocyclic ring contains at least one heteroatoms selected from N, O or S;
• each X1 is independently selected from the group consisting of C═O, —CH2—, —CHF—, and —CF2—;
• each X2 is independently selected from (C(R8)2)(1-3), NR8(C(R8)2)(1-3), —NH(C(R8)2)(1-3), —N(C1-6 alkyl)(C(R8)2)(1-3) or —N(haloC1-6 alkyl)(C(R8)2)(1-3);
• wherein each R8 is independently selected from the group consisting of H, deuterium, halogen, C1-C6 alkyl, CN, OR6, N(R6)2, C1-C6 haloalkyl, C3-C6 cycloalkyl, C1-C6 alkyl substituted by OR6, and C1-C6 alkyl substituted by N(R6)2;
• optionally 2 R8 on different carbon atoms may be taken together, along with the atoms to which they are attached, to form a 3- to 6-membered fused ring;
• and optionally 2 R8 on a single carbon atom may be taken together, along with the atom to which they are attached, to form a 3- to 6-membered spirocycle;
• each X3 is independently selected from the group consisting of COOR6, C(O)SR6, C(S)OR6, SO2R6, C(O)N(R9)2,
• and CN;
• and each R9 is independently selected from H, deuterium, COOR6, SO2R6, (CH2)1-3—C(═O)OR6, OR6, SR6, NH2, NH(C1-C6 alkyl), N(C1-C6 alkyl)2, O(C1-C6 alkyl), O(C6-C10 aryl), O(C1-C6 alkyl)-OR6, S(C1-C6 alkyl), S(C6-C10 aryl), S(═O)2R6, S(═O)20R6, P(═O)(R6)2, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C6-10 aryl, 3-8 membered heterocycloalkyl, or 3-10 membered heteroaryl.