US 2024/0198310 A1 · Library Preparation Systems and Associated Methods

Abstract

Library preparation systems and methods are disclosed. In an implementation, a modular bay for preparing a library of samples for sequencing, the modular bay comprising a contact dispenser and a working area comprising a working plate receptacle adapted to receive a working plate, a thermocycler, a magnet, and a drawer. The drawer comprising a consumables area adapted to receive a sample plate adapted to contain a sample, and a plurality of consumables for interacting with the sample in the working plate. The contact dispenser is linearly movable in a longitudinal direction between the consumables area and the working area, such that the contact dispenser is configured to (i) move the sample from the sample plate in the consumables area to the working plate in the working area, and (ii) move the plurality of consumables between the consumables area and the working plate in the working area.

Claims35

Dependent claims

A modular system for preparing a library of samples for sequencing, the modular system comprising:

a first assay bay for performing a first assay, comprising:
a first contact dispenser;
a first working area comprising:
a working plate receptacle;
a thermocycler;
and
a magnet;
and
a first drawer, the first drawer comprising a consumables area adapted to receive a working plate adapted to contain a sample, and a plurality of consumables for interacting with the sample;
a common bay, the common bay comprising an analyzer area including an imaging system;
and
a mover operatively coupled to the first assay bay and the common bay,
wherein the mover is movable in a first direction along the first assay bay and a second direction perpendicular to the first direction between the first assay bay and the common bay, such that the mover is configured to move the working plate from the consumables area to the working plate receptacle in the first working area,
wherein the first contact dispenser is linearly movable in the first direction between the consumables area and the first working area, such that the first contact dispenser is configured to move the plurality of consumables between the consumables area and the working plate in the working plate receptacle in the first working area, and
wherein the mover is further configured to move the sample from the first working area to the analyzer area for analysis by the imaging system.

12 more elements

A modular bay for preparing a library of samples for sequencing, the modular bay comprising:

a contact dispenser;
a working area comprising:
a working plate receptacle;
a thermocycler;
and
a magnet;
and
a drawer, the drawer comprising a consumables area adapted to receive a working plate adapted to contain a sample, and a plurality of consumables for interacting with the sample,
wherein the contact dispenser is linearly movable in a longitudinal direction between the consumables area and the working area, such that the contact dispenser is configured to move the plurality of consumables between the consumables area and the working plate in the working area.

6 more elements

An apparatus, comprising:

a system, comprising:
a consumables area comprising:
a consumables receptacle to receive a tip tray comprising a first tip and a second tip, a first plate having a well containing a sample, a second plate having a well, an index tray having a well containing indexes, and a bead tray having a well containing beads;
a mover;
a contact dispenser;
a stage to move the contact dispenser;
a plate receptacle;
a magnet;
a thermocycler;
and
an analyzer area comprising an imaging system.

8 more elements

Dependencies are inferred from the claim text.

Library Preparation Systems and Associated Methods

Life of this patent

Library Preparation Systems and Associated Methods

Life of this patent

Abstract

Claims35