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AssigneeDuke University
InventorsXiling SHEN, Aliesha O'RAW, James MORIZIO, Ashlesha DESHMUKH, Ayelet EREZ, Saar EZAGOURI
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A method for treating cachexia in a subject in need thereof includes stimulating the parasympathetic nervous system of the subject thereby treating cachexia in the subject. Stimulating the parasympathetic nervous system can increase expression of urea cycle enzymes in the liver of the subject. Parasympathetic nervous system stimulation can comprise stimulating the vagus nerve, for example, the cervical vagus nerve or the hepatic branch of the vagus nerve. Pulses can be delivered at a frequency ranging from 1 Hz to 10 Hz or at a frequency of about 5 KHz.
A method for treating cachexia in a subject in need thereof, the method comprising stimulating the parasympathetic nervous system of the subject thereby treating cachexia in the subject.
A method for mitigating weight loss due to cachexia in a subject in need thereof, the method comprising stimulating the parasympathetic nervous system in the subject thereby mitigating weight loss due to cachexia.
The method of claim 4, wherein the subject having cachexia who received stimulation to the parasympathetic nervous system experiences statistically significantly less weight loss than subjects having cachexia that received no stimulation.
A method for mitigating fat loss due to cachexia in a subject in need thereof, the method comprising stimulating the parasympathetic nervous system in the subject thereby mitigating fat loss due to cachexia.
A method for mitigating muscle wasting due to cachexia in a subject in need thereof, the method comprising stimulating the parasympathetic nervous system in the subject thereby mitigating muscle wasting due to cachexia.
A method for mitigating loss of appetite due to cachexia in a subject in need thereof, the method comprising stimulating the parasympathetic nervous system in the subject thereby mitigating loss of appetite.
A method for mitigating urea cycle dysregulation in a subject in need thereof due to cachexia, the method comprising stimulating the parasympathetic nervous system in the subject thereby mitigating urea cycle dysregulation due to cachexia in the subject.
Dependencies are inferred from the claim text.