US 2024/0197961 A1 · THIOLATED POLYSACCHARIDE DERIVATIVE HYDROGEL, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF

Abstract

Disclosed are a thiolated polysaccharide derivative hydrogel, a preparation method therefor, and use thereof. The thiolated polysaccharide derivative hydrogel is a thiolated hyaluronic acid polysaccharide derivative hydrogel or a thiolated chitin/chitosan derivative hydrogel. The thiolated hyaluronic acid polysaccharide derivative hydrogel is a polysaccharide hydrogel formed of one or two of thiolated hyaluronic acid derivatives and an aqueous solvent, and the thiolated chitin/chitosan derivative hydrogel is a polysaccharide hydrogel formed of one or two of thiolated chitin/chitosan derivatives and an aqueous solvent. The thiolated polysaccharide derivative hydrogel of the present invention is suitable for being used as a vitreous body substitute, and as the vitreous body substitute, can improve a shock absorption function, and can maintain the shape of an eyeball and press a retina in situ due to a good self-healing function and resilience.

Claims19

Dependent claims

A hydrogel formed from a thiolated polysaccharide derivative and an aqueous solvent, wherein the mass percentage concentration of the thiolated polysaccharide derivative in the aqueous solvent is 2% to 10%, and the thiol substitution degree of the thiolated polysaccharide derivative is 3% to 25%, and wherein the polysaccharide derivative is selected from the group consisting of hydroxyethyl hyaluronic acid, hydroxypropyl hyaluronic acid, acetyl hyaluronic acid, butyryl hyaluronic acid, aminoacetic hyaluronic acid, aminopropionic hyaluronic acid, aminobutyric hyaluronic acid, hydrazide hyaluronic acid, carboxymethyl chitosan, carboxyethyl chitosan, hydroxyethyl chitosan, hydroxypropyl chitosan, hydroxybutyl chitosan, succinyl chitosan, aminoacetic chitosan, aminopropionic chitosan, aminobutyric chitosan, hydroxyethyl succinyl chitosan, hydroxypropyl succinyl chitosan, hydroxybutyl succinyl chitosan, carboxymethyl chitin, carboxyethyl chitin, other hyaluronic acid derivatives, and other water-soluble chitin/chitosan derivatives.

A thiolated polysaccharide derivative hydrogel, selected from:

(i) a hydrogel formed from a thiolated hyaluronic acid derivative and an aqueous solvent, wherein the mass percentage concentration of the thiolated hyaluronic acid derivative in the aqueous solvent is 2.5% to 6%, and the thiol substitution degree of the thiolated hyaluronic acid derivative is 3% to 20%, and wherein the hyaluronic acid derivative is selected from the group consisting of hydroxyethyl hyaluronic acid, hydroxypropyl hyaluronic acid, acetyl hyaluronic acid, butyryl hyaluronic acid, aminoacetic hyaluronic acid, aminopropionic hyaluronic acid, aminobutyric hyaluronic acid, hydrazide hyaluronic acid and other hyaluronic acid derivatives;
and
(ii) a hydrogel formed from a thiolated chitin/chitosan derivative and an aqueous solvent, wherein the mass percentage concentration of the thiolated chitin/chitosan derivative in the aqueous solvent is 2% to 10%, and the thiol substitution degree of the thiolated chitin/chitosan derivative is 3% to 25%, and wherein the chitin/chitosan derivative is selected from the group consisting of carboxymethyl chitosan, carboxyethyl chitosan, hydroxyethyl chitosan, hydroxypropyl chitosan, hydroxybutyl chitosan, succinyl chitosan, aminoacetic chitosan, aminopropionic chitosan, aminobutyric chitosan, hydroxyethyl succinyl chitosan, hydroxypropyl succinyl chitosan, hydroxybutyl succinyl chitosan, carboxymethyl chitin, carboxyethyl chitin and other water-soluble chitin/chitosan derivatives.

A thiolated polysaccharide derivative having a thiol substitution degree of 3% to 25%, wherein the polysaccharide derivative is selected from the group consisting of hydroxyethyl hyaluronic acid, hydroxypropyl hyaluronic acid, acetyl hyaluronic acid, butyryl hyaluronic acid, aminoacetic hyaluronic acid, aminopropionic hyaluronic acid, aminobutyric hyaluronic acid, hydrazide hyaluronic acid, carboxymethyl chitosan, carboxyethyl chitosan, hydroxyethyl chitosan, hydroxypropyl chitosan, hydroxybutyl chitosan, succinyl chitosan, aminoacetic chitosan, aminopropionic chitosan, aminobutyric chitosan, hydroxyethyl succinyl chitosan, hydroxypropyl succinyl chitosan, hydroxybutyl succinyl chitosan, carboxymethyl chitin, carboxyethyl chitin, other hyaluronic acid derivatives and water-soluble chitin/chitosan derivatives.

A thiolated polysaccharide derivative selected from:

(i) a thiolated hyaluronic acid derivative having a thiol substitution degree of 3% to 20%, wherein the hyaluronic acid derivative is selected from the group consisting of hydroxyethyl hyaluronic acid, hydroxypropyl hyaluronic acid, acetyl hyaluronic acid, butyryl hyaluronic acid, aminoacetic hyaluronic acid, aminopropionic hyaluronic acid, aminobutyric hyaluronic acid, hydrazide hyaluronic acid and other hyaluronic acid derivatives;
and
(ii) a thiolated chitin/chitosan derivative having a thiol substitution degree of 3% to 25%, wherein the chitin/chitosan derivative is selected from the group consisting of carboxymethyl chitosan, carboxyethyl chitosan, hydroxyethyl chitosan, hydroxypropyl chitosan, hydroxybutyl chitosan, succinyl chitosan, aminoacetic chitosan, aminopropionic chitosan, aminobutyric chitosan, hydroxyethyl succinyl chitosan, hydroxypropyl succinyl chitosan, hydroxybutyl succinyl chitosan, carboxymethyl chitin, carboxyethyl chitin and other water-soluble chitin/chitosan derivatives.

Dependencies are inferred from the claim text.

Thiolated polysaccharide derivative hydrogel, preparation method therefor, and application thereof

Life of this patent

Thiolated polysaccharide derivative hydrogel, preparation method therefor, and application thereof

Life of this patent

Abstract

Claims19