Pet tracer

Abstract

The invention provides conjugated binding molecules comprising platelet-derived growth factor receptor beta (PDGF-Rβ) binding polypeptides conjugated to radionuclides chelated by a Restrained Complexing Agent (RESCA) chelator, wherein Aluminum-Fluorine-18 is the preferred radionuclide. The PDGF-Rβ binding polypeptide comprises a platelet derived growth factor receptor beta binding motif, PBM, which motif consists of an amino acid sequence as defined herein, wherein the PDGF-Rβ-binding polypeptide binds to PDGF-Rβ such that the KD value of the interaction is at most 1×10−6 M. Also provided are methods and uses of said conjugated binding molecule in imaging and diagnosis of PDGF-Rβ-related conditions, such as fibrosis.

Dependencies are inferred from the claim text.