A method for the manufacture of radionuclide-containing products having an identical desired activity of radioactivity at different times of application (ART+1, ART+2, ART+3, ART+4) with respect to a given calibration time (ART),
- characterized in that
- a radionuclide-containing concentrate is converted to a desired radionuclide-labeled product and thus a bulk solution is obtained which, in addition to the radionuclide-labeled product, contains all further components required for the intended use;
- the desired radionuclide is contained in the bulk solution in such an activity that a plurality of desired batches, each with a defined number of partial fillings, can be obtained from the bulk solution at a filling time, each batch of partial fillings at different times of application (ART+1, ART+2, ART+3, ART+4) in each case having an identical activity of the radionuclide, with respect to the calibration time (ART);
- the activity of the radionuclide-labeled product in the bulk solution is set to a latest desired time of application (ART+4);
- from the bulk solution containing the radionuclide-labeled product a first batch of partial fillings is taken at a first filling time prior to the time of application, which has an activity set to the latest time of application (ART+4) which, at its actual time of application, corresponds to the activity at the calibration time (ART);
- a diluting solution is provided, which, with the exception of the radionuclide-labeled product, includes all other components required for the intended use;
- the remaining bulk solution set to the latest desired time of application (ART+4) is diluted with the diluting solution in such a way that, at the time of filling, a desired reduced activity based on the latest time of application (ART+4) is set, so that for use at the preceding time of application a second batch of partial fillings is taken, which has an activity set to an earlier time of application (ART+3), which at its actual time of application (ART+3) corresponds to the activity at the calibration time (ART);
- the remaining bulk solution set to the earlier time of application (ART+3) is continued to be diluted stepwise with the diluting solution until the application time corresponds to the calibration time (ART);
- and
- further batches of partial fillings are respectively taken at each further time of application (ART+2, ART+1), which have an activity set to the respective time of application (ART+2, ART+1), the last batch having the activity of the calibration time (ART).