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US 2024/0197919 A1Published application
Recombinant aavs for delivery to central nervous system and brain vasculature
OwnerViviana Gradinaru, Xinhong Cheninventors
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Abstract
Disclosed herein include compositions and kits comprising recombinant adeno-associated viruses (rAAVs) with tropisms to the central nervous system with increased specificity and transduction efficiency, including endothelial cells of the neurovascular unit. Also described include methods of treating various diseases and conditions using the rAAVs.
Claims74
An adeno-associated virus (AAV) targeting peptide comprising an amino acid sequence that comprises at least 4 contiguous amino acids from a sequence selected from the group consisting of GNNTRSV (SEQ ID NO:
- 13), GNNTRDT (SEQ ID NO:
- 14) and TNSTRPV (SEQ ID NO:
- 15).
Dependencies are inferred from the claim text.