Nanoparticles as carrier-system for adjuvants/antigens
AssigneesLife Science Inkubator GmbH, Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts
InventorsArmin KÜBELBECK, Angelika RIEMER, Sebastian KRUSE, Eva FEIDT, Agnieszka GRABOWSKA, Ellen JUNGLAS
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Abstract
The disclosure relates to immunological compositions (immunostimulants) based on nanoparticles as carrier for adjuvants, optionally in combination with antigens or epitopes, in particular for the use of the compositions for immunoprophylaxis or immunotherapy.
Claims15
Composition comprising nanoparticles which are loaded with pharmaceutically acceptable compounds comprising polyinosinic:polycytidylic acid, poly(I:C) or any derivatives thereof, having silicon dioxide and functional groups on the surface, wherein
- the functional groups are capable to carry and/or stabilize both negative and positive charges of the pharmaceutically acceptable compounds,
- the zeta potential of the composition has a value of at least ±15 mV,
- the nanoparticles have a particle size below 150 nm.
Dependencies are inferred from the claim text.