Modified extracellular vesicles (evs) with improved half-life

Abstract

A modified Extracellular Vesicle (EV), preferably an exosome, comprising an albumin protein or fragment (e.g., an albumin domain) present on the surface of the EV membrane, preferably as part of a fusion protein (e.g., a transmembrane protein). The EV exhibits an improved circulating half-life, stability and shelf-life (both formulation and storage). Methods of making said EVs, as well as pharmaceutical compositions and their use.

Dependencies are inferred from the claim text.