Novel compositions enriched in gamma delta t cells, methods of preparation, and uses thereof
AssigneeAcepodia Biotechnologies Ltd.
InventorsCHING-WEN HSIAO, ZIH-FEI CHENG, TAI-SHENG WU, HAO-KANG LI, HSIU-PING YANG, CHIA-YUN LEE, SAI-WEN TANG, YI-HUNG OU, YAN-LIANG LIN, SHIH-CHIA HSIAO
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Abstract
Provided herein are novel compositions enriched in gdT cells with high therapeutic potential. Methods to produce such compositions and methods of uses thereof in adoptive immunotherapies are also provided.
Claims59
A method of manufacturing a cell population enriched in gamma delta T (gdT) cells, comprising culturing a source cell population comprising gdT cells in a medium supplemented with (i) a phosphoantigen, (ii) a cytokine, and (iii) human platelet lysate (“HPL”).
A population of cells comprising at least 70% gdT cells, wherein (1) the gdT cells express at least 400 DNAM-1 molecules per cell on average;
- (2) at least 30% of the gdT cells are CD69+;
- or both (1) and (2).
Dependencies are inferred from the claim text.