Neural control of adaptive immunity
AssigneeThe Feinstein Institutes for Medical Research
InventorsSangeeta S. Chavan, Kevin J. Tracey
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Abstract
The present invention provides methods for modulating antigen-specific antibody responses by administering to a mammal a compound that selectively either activates or inhibits a specific subset of sensory neurons that express TRPV1.
Claims22
A method of providing a vaccine adjuvant in a subject who is being administered an immunogen-specific vaccine, which comprises administering to said subject an immunogen-specific antibody production enhancing amount of a TRPV1 receptor agonist, thereby providing a vaccine adjuvant in the subject.
A method of increasing antibody production in a subject to at least one antigen contained in a vaccine that is being administered to said subject, which comprises administering to said subject an antibody-production increasing amount of a TRPV1 receptor agonist.
A method of treating an allergic or autoimmune disorder in a subject in need thereof, which comprises administering to said subject a therapeutically effective amount if a TRPV1 receptor antagonist.
Dependencies are inferred from the claim text.