Immunogenic compositions and methods for immunization against variants of severe acute respiratory syndrome coronavirus 2 (sars-cov-2)

An immunogenic composition against a severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), comprising an antigenic recombinant protein and an adjuvant selected from the group consisting of an aluminum-containing adjuvant, an unmethylated cytosine-phosphate-guanosine (CpG) motif, and a combination thereof, wherein the antigenic recombinant protein substantially consists of residues 14-1205 of spike protein of SARS-COV-2 Beta variant with proline substitutions at residues 983 and 984 and a “GSAS” substitution at residues 679-682 and a C-terminal T4 fibritin trimerization domain.