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US 2024/0197853 A1Published application
Multivalent cholera multiepitope fusion antigen (mefa) and methods of use
AssigneeThe Board of Trustees of the University of Illinois
InventorWeiping Zhang
Life of this patent
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Abstract
Compositions and methods for eliciting an immune response in a subject against Vibrio cholerae are provided. The compositions include fusion proteins with one or more epitopes from Vibrio cholerae, nucleic acids and vectors encoding the fusion proteins, pharmaceutical compositions, immunogenic compositions, and vaccines. In examples, the methods include administering a disclosed composition to a subject, such as a human.
Claims29
A fusion protein, comprising:
- a backbone protein, wherein the backbone protein comprises a consensus sequence having at least 90% sequence identity to SEQ ID NO:
- 4, and at least one heterologous Vibrio cholerae epitope.
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