Psoralen-inactivated neisseria gonorrhoeae vaccines and methods thereof
AssigneesWake Forest University Health Sciences, The United States as represented by the Secretary of the Navy
InventorsLeigh Ann Sanders, John W. Sanders, Marlena Westcott, Kevin Porter
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Abstract
The present invention relates to the fields of sexually transmitted disease and immunology. More specifically, but not exclusively, the invention provides a composition and methods to prepare and administer a vaccine for Neisseria gonorrhoede and/or other gram-negative bacteria such as by using psoralen-inactivated bacteria.
Claims28
An immunogenic composition comprising a crosslinked inactivated bacterium, wherein the bacterium has been crosslinked and inactivated by contact with psoralen or a psoralen derivative and exposure to ultraviolet (UV) irradiation.
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A method of making an immunogenic composition comprising:
- a) contacting a live bacterium to psoralen or psoralen derivative in a medium to produce a bacterium/psoralen mixture, and
- b) exposing the mixture of step (a) to an intensity of ultraviolet (UV) radiation for a time period sufficiently long to crosslink the live bacterium and render the live bacterium inactive.
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Dependencies are inferred from the claim text.