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US 2024/0197850 A1Published application
Salmonella vaccine
OwnerDebabrata BISWAS, Jungsoo JOO +1inventors
InventorsDebabrata BISWAS, Jungsoo JOO, Mengfei PENG
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Abstract
Provided are modified bacteria and methods of using the modified bacteria for prophylaxis or treatment of bacterial infections. The modified bacteria contain one or more genomic modifications such that the genomes of the bacteria are altered to encode and produce a holin protein and to encode and produce a lysozyme. The modified bacteria are illustrated using a type of Salmonella enterica (SE) in the form of autolytic SE serovar Typhimurium (S. typhimurium).
Claims20
Modified bacteria wherein the genomes of the bacteria are modified to encode a holin protein and to encode a lysozyme.
Dependencies are inferred from the claim text.