Peptide vaccines usable for hypercholesterolemia related diseases

A vaccine comprising at least one peptide consisting of 9 to 25 amino acid residues having the amino acid sequence

• (SEQ ID No. 1)
• X1X2X3WX4X5X6RX7(X8)m(X9)n,
• wherein
• X1 is an amino acid residue selected from the group of uncharged amino acid residues,
• X2 is an amino acid residue selected from the group of uncharged amino acid residues,
• X3 is an amino acid residue selected from the group of uncharged amino acid residues,
• X4 is an amino acid residue selected from the group consisting of asparagine, serine, alanine, glutamine and aspartic acid,
• X5 is an amino acid residue selected from the group consisting of leucine, glycine, alanine, tyrosine, aspartic acid, phenylalanine and valine,
• X6 is an amino acid residue selected from the group of hydrophilic, negatively charged amino acid residue,
• X7 is an amino acid residue selected from the group of uncharged amino acid residues,
• X8 is an amino acid residue selected from the group of uncharged amino acid residues selected from the group consisting of threonine, leucine, glutamine, alanine and serine,
• X9 is X10X1X12 or a C-terminal truncated fragment thereof consisting of 1 or 2 amino acid residues,
• X10 is any amino acid residue,
• X11 is any amino acid residue, X12 is any amino acid residue
• m is 0 or 1,
• n is 0 or 1, and
• SEQ ID No. 1 is not SIPWNLERITPPR or a C-terminal truncated fragment thereof,
• wherein said at least one peptide is coupled or fused to a pharmaceutically acceptable carrier.