Pharmaceutical composition for preventing or treating chronic renal disease including glucagon derivative

A method for treating chronic renal disease, comprising administering to a subject in need thereof a pharmaceutical composition, the pharmaceutical composition comprising a glucagon derivative and a pharmaceutically acceptable excipient,

• wherein the glucagon derivative is a peptide including an amino acid sequence of the following General Formula 1:
• (General Formula 1, SEQ ID NO:
• 46)
• X1-X2-QGTF-X7-SD-X10-S-X12-X13-X14-X15-X16-X17-
• X18-X19-X20-X21-F-X23-X24-W-L-X27-X28-X29-X30
• wherein X1 is tyrosine (Y);
• X2 is alpha-methyl-glutamic acid (a-methyl-glutamic acid), aminoisobutyric acid (Aib), D-alanine, glycine (G), N-methylglycine (Sar), serine (S), or D-serine;
• X7 is threonine (T), valine (V), or cysteine (C);
• X10 is tyrosine (Y) or cysteine (C);
• X12 is lysine (K) or cysteine (C);
• X13 is tyrosine (Y) or cysteine (C);
• X14 is leucine (L) or cysteine (C);
• X15 is aspartic acid (D), glutamic acid (E), or cysteine (C);
• X16 is glutamic acid (E), aspartic acid (D), serine (S), alpha-methyl-glutamic acid, or cysteine (C), or is absent;
• X17 is aspartic acid (D), glutamine (Q), glutamic acid (E), lysine (K), arginine (R), serine (S), cysteine (C), or valine (V), or is absent;
• X18 is alanine (A), aspartic acid (D), glutamic acid (E), arginine (R), valine (V), or cysteine (C), or is absent;
• X19 is alanine (A), arginine (R), serine (S), valine (V), or cysteine (C), or is absent;
• X20 is lysine (K), histidine (H), glutamine (Q), aspartic acid (D), arginine (R), alpha-methyl-glutamic acid, or cysteine (C), or is absent;
• X21 is aspartic acid (D), glutamic acid (E), leucine (L), valine (V), or cysteine (C), or is absent;
• X23 is isoleucine (I), valine (V), or arginine (R), or is absent;
• X24 is valine (V), arginine (R), alanine (A), cysteine (C), glutamic acid (E), lysine (K), glutamine (Q), alpha-methyl-glutamic acid, or leucine (L), or is absent;
• X27 is isoleucine (I), valine (V), alanine (A), lysine (K), methionine (M), glutamine (Q), or arginine (R), or is absent;
• X28 is glutamine (Q), lysine (K), asparagine (N), or arginine (R), or is absent;
• X29 is threonine (T);
• and
• X30 is cysteine (C), or is absent
• (with the proviso that when the amino acid sequence of General Formula 1 is identical to SEQ ID NO:
• 1 or SEQ ID NO:
• 12, it is excluded).