Chimeric molecule to treat sepsis and other inflammatory conditions
AssigneeThe Feinstein Institutes for Medical Research
InventorsPing Wang, Colleen Nofi, Monowar Aziz, Max Brenner
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Abstract
Milk fat globule-epidermal growth factor—factor VIII (MFG-E8) derived oligopeptides and pharmaceutical compositions containing the oligopeptides are provided for treating sepsis and inflammatory conditions.
Claims8
a method of treating a subject with sepsis or with an inflammatory condition comprising administering to the subject a therapeutic amount of a peptide selected from the group consisting of one or more of MOP3, MOP3H, MOP8 and MOP14, or a nucleic acid encoding the peptide, wherein
- MOP3 has the amino acid sequence
- (SEQ ID NO. 1)
- RGDSSSYKTWNLRAFGWY,
- MOP3H has the amino acid sequence
- (SEQ ID NO. 16)
- RGDSSSYKTWGLHLFSWN,
- MOP8 has the amino acid sequence
- (SEQ ID NO:
- 8)
- RGDVTGIITQGARDFGHI,
- and
- MOP14 has the amino acid sequence
- (SEQ ID NO:
- 14)
- RGDPFMARYVRVLPVSWH.
A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a peptide selected from the group consisting of one or more of MOP1, MOP2, MOP3, MOP3H, MOP4, MOP5, MOP6, MOP7, MOP8, MOP9, MOP10, MOP11, MOP12, MOP13, MOP14 and MOP15.
Dependencies are inferred from the claim text.