Methods and compositions for improving visual function in ocular diseases and disorders

A method of treating macular degeneration having geographic atrophy in an eye of an individual, comprising:

• administering a peptide (e.g., a composition comprising the peptide) comprising an amino acid sequence HHIYLGAVNYIY or a variant sequence thereof, or a pharmaceutically-acceptable salt of the peptide, to the eye of the individual.

A method of treating a loss in visual function (e.g., BCVA) in an eye of an individual having macular degeneration, comprising:

• administering a peptide (e.g., a composition comprising the peptide) comprising an amino acid sequence HHIYLGAVNYIY or a variant sequence thereof, or a pharmaceutically-acceptable salt of the peptide, to the eye of the individual.

A method of treating retinal detachment in an eye of an individual, comprising:

• administering a peptide (e.g., a composition comprising the peptide) comprising an amino acid sequence HHIYLGAVNYIY or a variant sequence thereof, or a pharmaceutically-acceptable salt of the peptide, to an eye of an individual, and performing surgery (e.g., standard of care surgery) on the eye of the individual.

A method of treating a loss in visual function in an eye of an individual having a retinal detachment, comprising:

• administering a peptide (e.g., a composition comprising the peptide) comprising an amino acid sequence HHIYLGAVNYIY or a variant sequence thereof, or a pharmaceutically-acceptable salt of the peptide, to an eye of an individual, and performing surgery (e.g., standard of care surgery) on the eye of the individual.