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US 2024/0197810 A1Published application
Multifunctional zwitterionic polymer conjugates
AssigneeKodiak Sciences Inc.
InventorsStephen A. Charles, Daniel Victor Perlroth, Lane A. Clizbe, Didier G. Benoit, Wayne To
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Abstract
The present invention provides random copolymers containing zwitterions and one or more functional agents, and methods of preparing such random copolymers.
Claims28
A random copolymer of Formula I:
- wherein
- each M1 and M2 are independently selected from the group consisting of acrylate, methacrylate, acrylamide, methacrylamide, styrene, vinyl-pyridine and vinyl-pyrrolidone;
- R1 is selected from the group consisting of H, L1-A1, LG1 and L1-LG1;
- each R2 is independently selected from the group consisting of H, C1-20 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 heteroalkyl, C3-8 cycloalkyl, C3-8 heterocycloalkyl, aryl, heteroaryl, A2, L2-A2, LG2, L2-LG2, I2 and L2-I2;
- ZW is a zwitterionic moiety;
- I is an initiator fragment and I′ is a radical scavenger, such that the combination of I-I′ is an initiator, I1, for the polymerization of the random copolymer of Formula I;
- alternatively, I′ is selected from the group consisting of H and C1-6 alkyl;
- I2 is an initiator;
- each of L1 and L2 is a linker;
- each of A1 and A2 is a functional agent;
- each of LG1 and LG2 is a linking group;
- subscripts x and y1 are each independently an integer of from 1 to 1000;
- subscript z is an integer of from 1 to 10;
- subscript s is an integer of from 1 to 100;
- subscript n is an integer of from 1 to 20;
- and
- wherein either R1 is L1-A1 or one of R2 is L2-A2.
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Dependencies are inferred from the claim text.