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US 2024/0197786 A1Published application
Mesenchymal Stem Cell Derived Exosomes And Methods
AssigneeNantBio, Inc.
InventorsPatrick Soon-Shiong, Francesco Curcio, Kayvan Niazi
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Abstract
Compositions and methods are presented that include exosomes from stem cells and/or tumor cells that were previously exposed to an inflammatory stimulus. Advantageously, such exosomes exhibit anti-inflammatory and analgesic effect when administered to an individual. Therefore, a preferred use of such exosomes will reduce the need for opioid analgesics, and reduce pain and inflammation.
Claims7
A method of manufacturing a pharmaceutical composition, comprising:
- exposing stem cells and/or tumor cells of an individual ex vivo in a culture medium to an inflammatory stimulus;
- harvesting exosomes from the culture medium;
- and
- formulating the harvested exosomes into a pharmaceutical composition suitable for injection or infusion.
1 more element
Dependencies are inferred from the claim text.