Methods of treatment and dosing of natural killer cell compositions
AssigneeIndapta Therapeutics, Inc.
InventorsGuy DIPIERRO, Austin BIGLEY
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Abstract
Provided herein are methods for treatment and uses involving dosing of compositions containing NK cells. Among the provided methods and uses are methods and uses for treating cancer, such as multiple myeloma or lymphoma, including in combination with an antibody therapeutic for the cancer.
Claims102
A method of treating multiple myeloma, the method comprising administering a composition of Natural Killer (NK) cells deficient in expression of FcRγ chain (g-NK cells) to a subject having multiple myeloma (MM), wherein the composition of g-NK cells is administered once weekly for a predetermined number of doses.
A method of treating multiple myeloma, the method comprising administering a composition of Natural Killer (NK) cells deficient in expression of FcRγ chain (g-NK cells) to a subject having multiple myeloma (MM), wherein the composition of g-NK cells is administered once weekly for a predetermined number of doses, and wherein the subject has received prior administration of at least one dose of an anti-CD38 antibody.
A method of treating lymphoma, the method comprising administering a composition of Natural Killer (NK) cells deficient in expression of FcRγ chain (g-NK cells) to a subject having lymphoma, wherein the composition of g-NK cells is administered once weekly for a predetermined number of doses.
A method of treating lymphoma, the method comprising administering a composition of Natural Killer (NK) cells deficient in expression of FcRγ chain (g-NK cells) to a subject having lymphoma, wherein the composition of g-NK cells is administered once weekly for a predetermined number of doses, and wherein the subject has received prior administration of at least one dose of an anti-CD20 antibody.
Dependencies are inferred from the claim text.