Methods and compositions for treating wounds utilizing chitosan compounds
AssigneeSynedgen, Inc.
InventorsShenda M. Baker, William P. Wiesmann, Ruth Baxter
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Abstract
Described herein are methods of treating wounds, the method comprising administering to a subject an effective amount of a composition comprising a soluble or derivatized chitosan wherein the soluble or derivatized chitosan when administered contacts the wound, thereby treating the wound.
Claims18
A method of treating a subject having a chronic disease or a symptom of thereof, the method comprising administering to a subject an effective amount of a composition comprising a soluble or derivatized chitosan, wherein the derivatized chitosan comprises a chitosan of the following formula (I):
- wherein:
- n is an integer between 20 and 6000;
- and
- each R1 is independently selected for each occurrence from hydrogen, acetyl, and a group of formula (II):
- or R1, when taken together with the nitrogen to which it is attached, forms a guanidine moiety,
- wherein R2 is hydrogen or amino;
- and
- R3 is amino, guanidino, C1-C6 alkyl substituted with an amino or guanidino moiety, or a natural or unnatural amino acid side chain,
- wherein at least 25% of R1 substituents are H, at least 1% of R1 substituents are acetyl, and at least 2% of R1 substituents are a group of formula (II), and
- wherein the molecular weight of the derivatized chitosan is between about 10,000 and 350,000 Da,
- thereby treating the subject.
A method of treating a wound in a subject, the method comprising administering to a subject an effective amount of a composition comprising a soluble or derivatized chitosan, wherein the derivatized chitosan comprises a chitosan of the following formula (I):
- wherein:
- n is an integer between 20 and 6000;
- and
- each R1 is independently selected for each occurrence from hydrogen, acetyl, and a group of formula (II):
- or R1, when taken together with the nitrogen to which it is attached, forms a guanidine moiety,
- wherein R2 is hydrogen or amino;
- and
- R3 is amino, guanidino, C1-C6 alkyl substituted with an amino or guanidino moiety, or a natural or unnatural amino acid side chain,
- wherein at least 25% of R1 substituents are H, at least 1% of R1 substituents are acetyl, and at least 2% of R1 substituents are a group of formula (II), and
- wherein the molecular weight of the derivatized chitosan is between about 10,000 and 350,000 Da,
- thereby treating the subject.
Dependencies are inferred from the claim text.