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US 2024/0197758 A1Published application
Psilocybin compositions, methods of making and methods of using the same
AssigneeCompass Pathfinder Limited
InventorsDavid Philip ELDER, Nigel RICHARDSON
Life of this patent
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Abstract
The present disclosure provides pharmaceutical compositions comprising a therapeutically effective amount of psilocybin and one or more pharmaceutically acceptable excipients. Methods of making such compositions and use thereof in treating depressive disorders are also disclosed.
Claims24
A pharmaceutical composition comprising:
- a therapeutically effective amount of psilocybin;
- and
- one or more pharmaceutically acceptable excipients,
- wherein, after storage of the composition at 40° C. and 75% relative humidity for one month, the potency of the psilocybin in the composition decreases by less than 5% and the mass balance of psilocybin and related substances is greater than 97%.
1 more element
2-38. (canceled)
A method of making a pharmaceutical composition comprising:
- a) direct mixing psilocybin and one or more pharmaceutically acceptable excipients to provide a blend, and
- b) filling a capsule with the blend to provide the pharmaceutical composition,
- wherein the content uniformity of the composition complies with the European Pharmacopeia 2.96. or USP <905>.
40-52. (canceled)
A pharmaceutical composition comprising:
- a therapeutically effective amount of psilocybin;
- and
- about 85% to about 99%, by weight, partially pregelatinized starch.
A pharmaceutical composition comprising:
- about 1% to about 10%, by weight, psilocybin;
- about 85% to about 99%, by weight, partially pregelatinized starch;
- and
- about 0.5% to about 2.0%, by weight, sodium stearyl fumarate.
1 more element
Dependencies are inferred from the claim text.