Methods of treatment with neuroactive steroids
AssigneePraxis Precision Medicines, Inc.
InventorsCarlos LOYA, Nicholas DEMARTINIS, Gabriel BELFORT
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Abstract
The disclosure relates to methods of treating depression, pain, a musculoskeletal disorder or a motor disorder such as essential tremor with Compound 1 or pharmaceutically acceptable salts thereof.
Claims33
A method of treating major depressive disorder (MDD), motor disorders, and/or musculoskeletal conditions in a patient in need thereof comprising orally administering a therapeutically effective amount of Compound 1:
- or a pharmaceutically acceptable salt thereof to a patient in need thereof, in the evening.
A method of reducing at least one side effect associated with administering a therapeutically effective amount of Compound 1:
- or a pharmaceutically acceptable salt thereof to a patient in need thereof, comprising administering Compound 1 in the evening, wherein the at least one side effect reduced is chosen from somnolence, sedation, dizziness, lightheadedness, fatigue, euphoria, feeling drunk, feeling abnormal, headache, cognitive disorder, disturbance of attention, memory impairment, slowed cognition, decreased alertness, constipation, or diarrhea.
A method of treating a motor disorder in a patient in need thereof comprising orally administering a therapeutically effective amount of Compound 1:
- or a pharmaceutically acceptable salt thereof to a patient in need thereof.
A method of treating a musculoskeletal condition in a patient in need thereof comprising orally administering a therapeutically effective amount of Compound 1:
- or a pharmaceutically acceptable salt thereof to a patient in need thereof.
A method of treating essential tremor in a patient in need thereof comprising orally administering a therapeutically effective amount of Compound 1:
- or a pharmaceutically acceptable salt thereof to a patient in need thereof.
Dependencies are inferred from the claim text.