Anticonvulsant activity of steroids
AssigneeThe Regents of the University of California
InventorsMICHAEL A. ROGAWSKI, Dorota ZOLKOWSKA
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Abstract
The present invention relates to methods of preventing, inhibiting, delaying. and/or mitigating seizures by administration of a steroid, e.g., a neurosteroid, e.g., allopregnanolone.
Claims28
A method of treating, reducing, and/or mitigating symptoms associated with and/or caused by traumatic brain injury, Alzheimer's disease, epilepsy, anxiety, fragile X syndrome, post-traumatic stress disorder, lysosomal storage disorders (Niemann-Pick type C disease), depression (including post-partum depression), premenstrual dysphoric disorder, alcohol craving, and smoking cessation in a subject in need thereof, comprising administration to the subject a steroid.
A method of treating, reducing, and/or mitigating symptoms associated with and/or caused by epilepsy, in a subject in need thereof, comprising administration to the subject a steroid.
A method of accelerating the termination or abortion of an impending seizure in a subject in need thereof, comprising administration to the subject a steroid.
A composition comprising or consisting essentially of a steroid and a cyclodextrin.
Dependencies are inferred from the claim text.