Method of inhibiting lipogenesis with ubiquitin-specific peptidase 24 inhibitor composition

A method of inhibiting hepatic lipid accumulation with a USP 24 inhibitor composition, wherein the USP 24 inhibitor composition comprises carbonyl-substituted phenyl compound and/or its salt as an active ingredient, as shown in formula (I):

• in formula (I), X1 represents a single bond, n1 represents an integer of 1 or 2, Y represents a monovalent group, X2 represents a hydrogen atom or a hydroxyl group, and the salts of said carbonyl-substituted phenyl compound are selected from a group consisting of oxalates, phosphates, sulfates, and hydrochlorides, and
• wherein when X1 represents the single bond, n1 represents the integer 1, in formula (I-1), R1 represents an alkyl piperazine group as shown in formula (I-2), where # represents a connecting point with one nitrogen atom of the thiazine group (I-1), and n2 represents an integer from 1 to 4
• wherein when X2 represents a hydrogen atom, Y represents a monovalent group having a thiazine group as shown in formula (I-1), and * in formula (I-1) represents a connecting point with X1,
• wherein the carbonyl-substituted phenyl compound is administered to an individual at an effective dose of 5 mg/kg body weight to 20 mg/kg body weight.