Combination therapy with a mek inhibitor and a src inhibitor for the treatment of colorectal cancer
AssigneesYeda Research and Development Co. Ltd., The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center
InventorsRavid STRAUSSMAN, Nancy GAVERT, Yaara ZWANG
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Abstract
A method of treating colorectal cancer (CRC) is provided. The method comprises administering to a subject in need thereof a therapeutically effective amount of a Mitogen/extracellular signal-regulated kinase (MEK) inhibitor and a SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase (SRC) inhibitor, wherein cancer cells of the subject express an amount of SRC p419 above a predetermined level and do not express a KRAS G12 mutation, thereby treating the CRC.
Claims15
A method of treating colorectal cancer (CRC), the method comprising administering to a subject in need thereof a therapeutically effective amount of a Mitogen/extracellular signal-regulated kinase (MEK) inhibitor and a SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase (SRC) inhibitor, wherein cancer cells of the subject express an amount of SRC p419 above a predetermined level and do not express a KRAS G12 mutation, thereby treating the CRC.
A method of selecting treatment to colorectal cancer (CRC) for a subject in need thereof, the method comprising determining a level of SRC p419 and a RAS mutation to exclude a KRAS G12 mutation in cancer cells of the subject, wherein a SRC p419 level above a predetermined level and an absence of a KRAS G12 mutation, is indicative of an efficacious treatment with of a MEK inhibitor and a SRC inhibitor.
Dependencies are inferred from the claim text.