External anti-inflammatory coupling compound drug, and preparation method therefor and use thereof

An anti-inflammatory compound, or a stereoisomer, tautomer, nitrogen oxide thereof, metabolite, prodrug, pharmaceutically acceptable salt, or solvate thereof, having a structure shown in general formula (I):

• A-Y—B (I)
• wherein, A is a group after dehydrogenation of an amine compound having JAK inhibitory activity;
• Y is a direct connection;
• or —(CH2)—O— or —(CH2)—;
• B is a group formed by means of dehydroxylation of a carboxy-containing carboxylic acid compound B1, or a group formed by means of dehydrogenation of a hydroxy-containing compound B2;
• and
• wherein, in the case where the carboxylic acid B1 is dehydroxylated to form a group, the Y group is a direct connection or —(CH2)—O—;
• or in the case where the hydroxy-containing compound B2 is dehydrogenated to form a group, the Y group is —(CH2)—.