ALK-5 Inhibitors and Uses Thereof

A compound of Formula (I):

• or a pharmaceutically acceptable salt thereof, wherein:
• R1 is a C1-C5 alkyl, C3-C5 carbocycle, or halogen;
• R2 is —H, a halogen, a C1-C3 alkyl optionally substituted with one or more —F, or a cyclopropyl optionally substituted with one or more —F;
• R3 is —H, a halogen, a C1-C3 alkyl optionally substituted with one or more —F, or a cyclopropyl optionally substituted with one or more —F;
• and
• Ring G is
• wherein
• indicates the point of attachment of Ring G to the —N(H)—;
• or
• Ring G is a C6-C10 aryl optionally substituted with:
• (i) one or more halogens;
• (ii) a sulfonamide;
• (iii) a monocyclic, bicyclic or spirocyclic C3-C10 carbocycle which is optionally substituted with one or more C1-C6 alkyl or C3-C6 carbocycle which are optionally substituted with hydroxy or one or more halogen, wherein said carbocycle is attached to Ring G by a single bond or a methylene or ethylene linker at a position on Ring G which is meta- or para- to the —N(H)— attached to Ring G;
• or
• (iv) a monocyclic, bicyclic, bridged or spirocyclic C3-C10 heterocycle which may contain up to 3 heteroatoms independently selected from N and O and which is optionally and independently substituted with one or more C1-C6 alkyl or C3-C6 carbocycle which are optionally substituted with hydroxy or one or more halogen, wherein said heterocycle is attached to Ring G by a single bond or a methylene or ethylene linker at a position on Ring G which is meta- or para- to the —N(H)— attached to Ring G.