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US 2024/0197707 A1Published application
Compositions and their Use for the Treatment of A1-Antitrypsin Deficiency
AssigneeCentessa Pharmaceuticals (UK) Limited
InventorsNigel RAMSDEN, David John FOX, James Andrew HUNTINGTON
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Abstract
The invention relates to pharmaceutical compositions comprising (S)-1-(2-(trifluoromethyl)phenyl)sulfonyl)piperidine-3-carboxylic acid and their medical use, for example for use in the treatment of α1-antitrypsin deficiency (AATD).
Claims7
A pharmaceutical composition comprising the compound (S)-1-((2-(trifluoromethyl)phenyl)sulfonyl)piperidine-3-carboxylic acid
- for use in treating a disease or disorder characterised by low plasma levels of α1-antitrypsin (A1AT) in a human subject, wherein the composition is administered to the human subject at a daily dose of about 1-6 mg/kg.
The pharmaceutical composition for use according any of the preceding claims, in which the composition is administered in oral form or intravenously.
Dependencies are inferred from the claim text.