Treatment of acute anxiety with an alpha-7 nicotinic acetylcholine receptor modulator
AssigneeVanda Pharmaceuticals Inc.
InventorsMihael H. Polymeropoulos, Yunsheng He, Christos Polymeropoulos
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Abstract
Disclosed herein are methods of treatment or prevention of acute anxiety in an individual in need thereof. Such methods include administering to the individual an alpha 7 nicotinic acetylcholine receptor (α7 nAChR) modulator at a therapeutic dose to treat or prevent manifestations of the acute anxiety and symptoms thereof.
Claims20
A method for treating an individual suffering from or susceptible to acute anxiety, comprising:
- determining for said individual a dose of an α7 nAChR modulator providing an exposure level of the modulator known to be effective to ameliorate or prevent acute anxiety or a symptom thereof;
- and
- administering to the individual the α7 nAChR modulator at the dose found to provide the individual said exposure level.
In a method of treating an individual suffering from or susceptible to acute anxiety, by administering to the individual an alpha 7 nicotinic acetylcholine receptor (α7 nAChR) modulator, at a dose effective to ameliorate or prevent the acute anxiety or a symptom thereof, the improvement comprising:
- selecting the individual for treatment with the α7 nAChR modulator based on whether or not the sex of the individual is female.
Dependencies are inferred from the claim text.