Rifabutin treatment methods, uses, and compositions
AssigneeBioversys AG
InventorsGlenn E. Dale, Sergio Lociuro, Marc Gitzinger, Stefano Biondi, Marilyne Bourotte
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Abstract
The invention provides formulations containing highly concentrated solutions of rifabutin and methods of making such formulations. The invention also provides methods of using such formulations to treat a bacterial infection in a subject.
Claims16
A rifabutin formulation produced from a rifabutin powder in the presence of an acid, water, and a solvent suitable to promote dissolution of the rifabutin.
A method of preparing a formulation of rifabutin, the method comprising:
- preparing a solution comprising a solvent, water and an acid;
- and
- adding said solution to rifabutin powder, thereby causing the rifabutin to dissolve in the solution.
A method of preparing a formulation of rifabutin, the method comprising:
- preparing a solution comprising water and an acid;
- and
- adding said solution to a rifabutin solution in a solvent, thereby producing an aqueous rifabutin formulation.
A method of treating a bacterial infection in a subject, the method comprising administering a therapeutically effective amount of rifabutin in an injectable formulation or by inhalation.
Dependencies are inferred from the claim text.