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US 2024/0197661 A1Published application
Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof
AssigneeArbor Pharmaceuticals, LLC
InventorsPeter A. VIRSIK, Sami KARABORNI, Laura Elizabeth BAUER, Chen MAO, Ching Wah CHONG
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Abstract
Methods of treating psoriasis with sustained release compression coated tablet dosage forms comprising certain MHF prodrugs are provided.
Claims20
1-13. (canceled)
A method of treating psoriasis comprising orally administering a tablet to a subject in need thereof, wherein the tablet comprises:
- (A) a core comprising (N,N-diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate in a dose of about 100 mg or about 200 mg;
- and
- (B) a compressed coating layer surrounding the tablet core, wherein the compressed coating layer
- (i) comprises hydroxypropyl methyl cellulose;
- and
- (ii) is substantially free of ionizable polymer having carboxylic acid moieties;
- wherein (N,N-diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate is the sole active ingredient in the tablet;
- wherein the tablet, when subjected to an aqueous solution free of (N,N-diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate, releases at most 20% of the (N,N-diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate from the core over a period of 2 hours.
5 more elements
Dependencies are inferred from the claim text.