Drug delivery for intervertebral disc pain management
AssigneeGlobus Medical, Inc.
InventorsDavid C. Paul, Amy Hill
Life of this patent
Estimating the term…
Abstract
Biomaterials, implants, methods of making the biomaterial and implants, methods of providing pain relief by administering the biomaterial or implant to a patient, and kits that include such biomaterials, implants, or components thereof. The biomaterials may include microparticles including one or more active pharmaceutical agents, such as anesthetics, antibiotics, and corticosteroids, which help to provide pain relief over an extended period of time. The biomaterials may be applied directly to the intervertebral disc or in the disc space to provide direct therapy for the management of disc pain.
Claims20
A composition for pain management comprising:
- an implant comprising a plurality of biodegradable microparticles loaded with active pharmaceutical agents including an anesthetic agent, an antibiotic agent, and an anti-inflammatory agent, wherein the plurality of biodegradable microparticles provides controlled release of the active pharmaceutical agents to maintain a therapeutic target dose of each agent for a given duration of time, and wherein the composition is configured to be applied directly to a pain site for pain relief,
- wherein the implant is positioned in a disc spaced between adjacent vertebrae, and wherein the implant engages endplates of the adjacent vertebrae and facilitates intervertebral fusion until the implant is fully resorbed.
A composition for pain management comprising:
- an implant comprising:
- a plurality of biodegradable microparticles loaded with active pharmaceutical agents including an anesthetic, an antibiotic, and a corticosteroid;
- and
- an excipient or carrier for supporting the biodegradable microparticles,
- wherein the composition is configured to be applied directly to a pain site for extended pain relief, wherein the time-release profile of the anesthetic is faster than the antibiotic and corticosteroid to provide acute relief, and wherein the time-release profile of the corticosteroid is longest to provide long term pain relief,
- wherein the implant is positioned in a disc spaced between adjacent vertebrae, and wherein the implant engages endplates of the adjacent vertebrae and facilitates intervertebral fusion until the implant is fully resorbed.
A method of alleviating disc pain in a subject in need thereof, the method comprising:
- providing an implant comprising:
- a plurality of biodegradable microparticles loaded with active pharmaceutical agents including an anesthetic, an antibiotic, and a corticosteroid;
- and
- an excipient or carrier for supporting the biodegradable microparticles,
- wherein the composition is configured to be applied directly to a pain site for extended pain relief, wherein the time-release profile of the anesthetic is faster than the antibiotic and corticosteroid to provide acute relief, and wherein the time-release profile of the corticosteroid is longest to provide long term pain relief,
- positioning the implant in a disc spaced between adjacent vertebrae, and wherein the implant engages endplates of the adjacent vertebrae and facilitates intervertebral fusion until the implant is fully resorbed,
- wherein the implant includes a therapeutically effective amount of at least one composition containing at least one microparticle loaded with at least one active pharmaceutical agent including one or more anesthetics, antibiotics, and corticosteroids.
Dependencies are inferred from the claim text.