Implantable Device and Therapeutic System with Passive Oxygenation

A therapeutic system comprising:

• an implantable device for providing a therapeutic agent, the implantable device configured to be implanted subcutaneously along a skin region, and the implantable device comprising:
• a container configured to contain a plurality of cells capable of producing the therapeutic agent within an interior region of the container, the container defining:
• first pores defined by an interior wall portion of the container, the first pores having a first average size that (i) allows passage of the therapeutic agent and oxygen through the first pores and (ii) prevents passage of immune cells through the first pores, and
• second pores defined by an exterior wall portion of the container, the second pores having a second average size that is larger than the first average size, and the second pores being sized to promote vascularization and oxygen transfer along the exterior wall portion;
• and
• an accessory device configured to cooperate with the implantable device for promoting delivery of oxygen to the plurality of cells.