Closure system, and manufacturing method of closure device

A manufacturing method of a closure device for closing a hole or duct in a tissue in a heart or for closing a hole or duct in a tissue continuous to the heart, wherein:

• the closure device comprises a first plate to cover the hole or duct;
• the first plate comprises a first center part, and a first extension part extending around the first center part and containing a resin having elastic restorability;
• the elastic restorability is a property by which the first extension part returns from a state in which the first extension part is folded such that surface portions of the first extension part face to each other, to a state in which the first extension part is extended around the first center part;
• the manufacturing method comprises a producing step that produces the closure device based on information on a shape and a position of the hole or duct in the tissue;
• and
• the producing step comprises a first plate designing step using a learning model that is trained with a training data in such a manner that the information on the shape and the position of the hole or duct in the tissue are inputted to the learning model, and that the learning model outputs design information including a planar shape, a thickness, and a material of the first extension part, wherein the training data includes shapes and positions of holes or ducts in tissues as input objects, and wherein the training data includes design information including planar shapes, thicknesses, and materials of first extension parts as output values.